Low Power Mode in STM32WB

           I am using STM32WB for My Application, I want to initailly mcu is stop mode or sleep mode,when external interrupt (switch) is triggered its wakeup from low power mode.After wake up re-installize the System Clock for Mcu running configured clock frequency.

In my case its working well without configure STM32_WPAN (BLE) in STM32Cube Mx, When ever i use both Stop mode and BLE its not working while wakeup trigger is applied.

I tried all the ways of Sleep, Stop and Shutdown mode ,all are gives same response.I hope you understand my problem and give suggestion.

int main(void)
{
 /* USER CODE BEGIN 1 */

 /* USER CODE END 1 */

 /* MCU Configuration--------------------------------------------------------*/

 /* Reset of all peripherals, Initializes the Flash interface and the Systick. */
 HAL_Init();
 /* Config code for STM32_WPAN (HSE Tuning must be done before system clock configuration) */
 MX_APPE_Config();

 /* USER CODE BEGIN Init */

 /* USER CODE END Init */

 /* Configure the system clock */
 SystemClock_Config();

/* Configure the peripherals common clocks */
 PeriphCommonClock_Config();

 /* IPCC initialisation */
 MX_IPCC_Init();

 /* USER CODE BEGIN SysInit */

 /* USER CODE END SysInit */

 /* Initialize all configured peripherals */
 MX_GPIO_Init();
 MX_DMA_Init();
 MX_RTC_Init();
 MX_LPUART1_UART_Init();
 MX_TIM1_Init();
 MX_RF_Init();
 /* USER CODE BEGIN 2 */
 HAL_PWREx_EnterSHUTDOWNMode();
 SystemClock_Config();
 HAL_TIM_Base_Start_IT(&htim1);
 /* USER CODE END 2 */

 /* Infinite loop */
 /* USER CODE BEGIN WHILE */
 while (1)
 {
	 if(gWakeupFlag==1)
	 {
		 if(gInitFlag==0)
		 {
			 MX_APPE_Init();
			 gInitFlag=1;
		 }
		 MX_APPE_Process();
	 }


 /* USER CODE END WHILE */

 /* USER CODE BEGIN 3 */
 }
 /* USER CODE END 3 */
}