More than likely it's a failure of the I2C. Unless you pay particular attention to the pull-ups, line thickness and line length, noise will cause a 'glitch' which results in a false bit, and one ends up with a Bus-stuck-low - which can be checked with a scope. Most MCUs have a mechanism to clear this -or you can put a bunch of zeros on the bus until it clears. My first rule of thumb - a bigger pull-up. (But you have to get a scope and look at the slope and the noise to be sure.)
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