Hello @hhell.1,
First could you try connecting under reset. If that doesn't work try pulling BOOT0 high (connect CN11 pin 5 to 7), unplug/plug the board to your PC and try connecting in hotplug mode. If you're able to connect, follow the steps detailed in AN5347 section 9.1.2 (page 21) to do a TZEN/RDP regression with a boot from RSS.
Let me know if you find this helpful.
Aziz
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