using the ADC on STM32L412

Im trying to upgrade the chip I'm using from an STM32F013 to an STM32L412 because I need more speed. I trying to get the ADC running, but having some problems - I check for the EOC flag to be set with a while loop but it stays in the loop forever. I really can't see what I have missed - can anyone help? My setup and code is below

int main(void)
{
 HAL_Init();
 SystemClock_Config();
 MX_ADC1_Init();
 
 ADC1->CR |= 1>>0; // enable ADC
 
 while (1)
 {
	 ADC1->CR |= ADC_CR_ADSTART;
	 	 	 while(((ADC1->ISR) & 0b00000100)==0)
	 	 	 {
	 	 	 }
	 	 	Result1 = ADC1->DR;
	 		ADC1->CR |= ADC_CR_ADSTART;
 }
}
 
 
static void MX_ADC1_Init(void)
{
 ADC_MultiModeTypeDef multimode = {0};
 ADC_ChannelConfTypeDef sConfig = {0};
 
 /** Common config 
 */
 hadc1.Instance = ADC1;
 hadc1.Init.ClockPrescaler = ADC_CLOCK_ASYNC_DIV1;
 hadc1.Init.Resolution = ADC_RESOLUTION_12B;
 hadc1.Init.DataAlign = ADC_DATAALIGN_RIGHT;
 hadc1.Init.ScanConvMode = ADC_SCAN_DISABLE;
 hadc1.Init.EOCSelection = ADC_EOC_SINGLE_CONV;
 hadc1.Init.LowPowerAutoWait = DISABLE;
 hadc1.Init.ContinuousConvMode = DISABLE;
 hadc1.Init.NbrOfConversion = 1;
 hadc1.Init.DiscontinuousConvMode = DISABLE;
 hadc1.Init.NbrOfDiscConversion = 1;
 hadc1.Init.ExternalTrigConv = ADC_SOFTWARE_START;
 hadc1.Init.ExternalTrigConvEdge = ADC_EXTERNALTRIGCONVEDGE_NONE;
 hadc1.Init.DMAContinuousRequests = DISABLE;
 hadc1.Init.Overrun = ADC_OVR_DATA_PRESERVED;
 hadc1.Init.OversamplingMode = DISABLE;
 if (HAL_ADC_Init(&hadc1) != HAL_OK)
 {
 Error_Handler();
 }
 /** Configure the ADC multi-mode 
 */
 multimode.Mode = ADC_MODE_INDEPENDENT;
 if (HAL_ADCEx_MultiModeConfigChannel(&hadc1, &multimode) != HAL_OK)
 {
 Error_Handler();
 }
 /** Configure Regular Channel 
 */
 sConfig.Channel = ADC_CHANNEL_5;
 sConfig.Rank = ADC_REGULAR_RANK_1;
 sConfig.SamplingTime = ADC_SAMPLETIME_2CYCLES_5;
 sConfig.SingleDiff = ADC_SINGLE_ENDED;
 sConfig.OffsetNumber = ADC_OFFSET_NONE;
 sConfig.Offset = 0;
 if (HAL_ADC_ConfigChannel(&hadc1, &sConfig) != HAL_OK)
 {
 Error_Handler();
 }
}