I found the problem.If you run the debug, you should check your debug configuration and use "STM32 Cortex-M C/C++ Application".

I have the same issue too.​A month ago, I used NUCLEO to test some function and the program progress work success.But few days ago, STM32CubeIDE suddenly can not execute program and pop-out the message below, and I have no idea how to solve this prob...