Posted on November 18, 2016 at 14:28If you are referring to the on-chip 12-bit DAC, all you need is a DC-Blocking capacitor in series with each DAC output pin. Also make sure your Binary data is offset by 2048, so that the output can swing peak-to-peak.
The max output of the on-chip DAC is 3.3 volts peak-to-peak, which is a bit on the high side to drive a line-level input such as those on PC powered speakers, but I have never run into a case where I have destroyed an amp or mixer input channel by applying the DAC output directly.
As far as overloading the DAC, just make sure to enable the DAC buffered output when you initialize the DAC. I have driven 32-ohm headphones directly from the DAC. with just a drop in voltage swing only. Just avoid running the DAC into a dead short circuit!
