It is possible, you're wasting your time, or more generally others. There aren't likely to be many examples, cause it's a bad idea, and I expect a lot of people have wasted a lot of time, and have left disappointed. Experiential learners might need to fail to determine the path was poorly chosen.
It generally gets into your ability to deblock the data, and overwrite in place, and the ability to juggle the data in a timely fashion whilst not causing the interface to stall.
The internal memories are often small and slow, availability of RAM might also limit options. Ditto for External QSPI NOR Flash devices, perhaps easier to manage, but have slow erase/write.
RAM/SDRAM based drive, reasonably easy, preformatting can be a little complex.
MSC thru to SD Card, again reasonably easy, most examples implement this, throughput generally not spectacular.
