Does VL53L0X have ROI unit? No. The only TimeOfFlight sensor from ST with an ROI is the VL53L1X.
How do I use SPAD unit in VL53L0X? The SPAD array on this chip is pretty much all or nothing. As there is no lens on the device, the light is not directed and there is no way to tell from where the light came.
If I use vl6180x, do I get the results as a nearest object? On all the ST ToF sensors (VL6180, VL53L0X and the VL53L1X), the photon distances are averaged. This technique will get more photons from the nearest, biggest object, so you will get a weighted average. So it's pretty close to the nearest object, but not quite.
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