Solved
Hello
Sorry for my late replay. To enable SMPS on the STM32U575ZIT6Q using the Pinout & Configuration menu on the .ioc file of your project, you have to go to Power and Thermal -> PWR -> Low Power -> check the Case Power saving mode -> on the Power Saving tab under Configuration, change the Power Regulator from LDO to SMPS. for the Pop-up message, you can ignore it clicking on the yes button of the Message. It is just a warning to have better configurations. You can't disable it but you are not obliged to follow it.

Best Regards.
STTwo-32
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