Whether Re-initialization of system clock required after adjusting the calibration value?

[DKPitc]

Hi I am using STM32L082, in my application I would like to calibrate the MCU once/twice per day. I would like to know whether clock re-initialization is required after adjusting the calibration value using "__HAL_RCC_MSI_CALIBRATIONVALUE_ADJUST(_MSICALIBRATIONVALUE_)" or "__HAL_RCC_HSI_CALIBRATIONVALUE_ADJUST(_HSICALIBRATIONVALUE_)".

I have gone through HAL layer user manual and the App note for internal clock calibration. I could not get the required detail. Can anyone help me with providing this information?