I would say: bad idea , dont do this.
A high speed connection going straight to a cpu , that can be touched by anything....no way to go.
Why not using a standard usb-A port , with grounded metal around, as everybody is using?

If you insist on a game: > how long will it survive < --- ok, try with as much protection as possible.
Your PESD2USB3UV triggers at 8V -- the U595 might not survive the first test pulse.
I use the esd-diode device , thats on nucleo boards : (vbus connected to usb V+ )

+ your diode at input + small resistor (33 r , or so) close to the input contact points (to reduce current peak to the usbcl6) ---- then try to kill it. It has to survive > 10kV body discharge, 100 times, as this is easily reached in real world.
If you loose the game, take a usb-A port + usblc6 protector. (This combination works on more than 500 boards at my company.)
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