Hello @S-Bat,
First I'm confused exactly what is meant by "bootloader is activated", what boot mode does that refer to?
AN2606 STM32 microcontroller system memory boot mode. "bootloader is activated" means the system memory boot mode is enabled by applying pattern 1 configuration.
In STM32F446 MCUs, BOOT0 is a dedicated pin while BOOT1 is shared with a GPIO pin. Once BOOT1 has been sampled, the corresponding GPIO pin is free and can be used for other purposes.
To activated the Main Flash memory boot mode, you need BOOT0=0.

The below figure shows the external connection required to select the boot memory of the STM32F4xxxx

Thank you.
Kaouthar
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