On the STM32U5xx, keep ADCx->CCR PRESC = 0, do not use the prescaler.
I'm using the ADC1 and ADC4 with PLL as kernel clock (MSIS 24MHz pll'ed to 32768 Hz watch crystal / 2 x (11 + 2163/8192) / 24) = 5.632 MHz).
The ADC1 in combination with the MDF "looses" every second sample.
The ADC4 never gets ready.
The errata sheet (https://www.st.com/content/ccc/resource/technical/document/errata_sheet/group0/70/0e/1e/74/c5/d2/4d/95/DM00648236/files/DM00648236.pdf/jcr:content/translations/en.DM00648236.pdf)
mentions that you can use prescaler values greater 0 when not using the ADCs at the same time. But there seem to be more conditions when the prescaler value will interfere.
