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Well, it looks like the circuit you put in is from here, doesn't it?
The operational amplifier used there provides an offset voltage of 10µV, while the internal operational amplifier of the STM32L476 is specified with 3 mV over the temperature range. Why not configure it in mode Standalone and give it a try if the spec is fine with you.
However, there is also an external opamp with an even better offset from STMicroelectronics: the TSZ121/122/124
Good luck!
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/Peter
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