No timers on custom F091 hardware, debug wonky

I have a custom board with an STM32F091. I cannot seem to get any timer action, and the debugger is unstable. I am using the internal clock source and CubeMX to configure. I am just looking to make a 1mS timer for a simple scheduler. I have tried timer6, 14, and Systick but I get nothing. What can cause all of these symptoms? Something in the hardware?