stm32h743vit6 can not connect to stm32cubeprogrammer

[guan]

I designed a pub board for stm32h743vit6, I connected mcu to stm32programmer via usart1,and sad port also reserved.But when I clicked "connect",it showed mistake:00:37:16:773 : RTS low
00:37:16:774 : DTR Low
00:37:16:833 : Serial Port cu.usbmodem0000637289221 is successfully opened.
00:37:16:833 : Port configuration: parity = even, baudrate = 115200, data-bit = 8, stop-bit = 1.0, flow-control = off
00:37:16:833 : No Init bits value is : 0
00:37:16:833 : Sending init command:
00:37:16:833 : #byte 0x7F sent successfully to target
00:37:18:834 : Wait ends after 1 loop, dataready = 0, delay = 2001
00:37:18:835 : Timeout error occured while waiting for acknowledgement.
00:37:18:835 : No response from target received
00:37:18:836 : Retrying UART init connection...
00:37:18:836 : #byte 0x7F sent successfully to target
00:37:18:847 : Wait ends after 1 loop, dataready = 1, delay = 11
00:37:18:848 : #ack Received response from target: 0x1f
00:37:18:848 : Activating device: OK
00:37:18:848 : Board : --
00:37:18:848 : Sending GetID command and its XOR:
00:37:18:848 : #byte 0x02 sent successfully to target
00:37:18:848 : #byte 0xFD sent successfully to target
00:37:18:859 : Wait ends after 1 loop, dataready = 1, delay = 11
00:37:18:859 : #ack Received response from target: 0x79
00:37:18:859 : Received 4 data bytes from target : 0x01045079
00:37:18:859 : Chip ID: 0x450
00:37:18:859 : Sending Get command and its XOR:
00:37:18:860 : #byte 0x00 sent successfully to target
00:37:18:860 : #byte 0xFF sent successfully to target
00:37:18:874 : Wait ends after 1 loop, dataready = 1, delay = 14
00:37:18:874 : #ack Received response from target: 0x79
00:37:18:874 : Received 1 data bytes from target : 0x0b
00:37:18:874 : size of bytes in the response: 11
00:37:18:874 : Received 13 data bytes from target
00:37:18:874 : Full received response: 0b31000102112131446373829279
00:37:18:874 : BootLoader protocol version: 3.1
00:37:18:874 : #byte 0x11 sent successfully to target
00:37:18:874 : #byte 0xEE sent successfully to target
00:37:19:000 : #data sent successfully to target: 0x0800000008
00:37:20:011 : Sending GetID command and its XOR:
00:37:20:011 : #byte 0x02 sent successfully to target
00:37:20:011 : #byte 0xFD sent successfully to target
00:37:20:020 : Wait ends after 1 loop, dataready = 1, delay = 8
00:37:20:020 : #ack Received response from target: 0x1f
00:37:20:020 : Response received from device: NACK
00:37:20:020 : Error: GETID command not acknowledged!
00:37:20:145 : Reemission of GetID command
00:37:20:146 : Sending GetID command and its XOR:
00:37:20:146 : #byte 0x02 sent successfully to target
00:37:20:146 : #byte 0xFD sent successfully to target
00:37:20:161 : Wait ends after 1 loop, dataready = 1, delay = 14
00:37:20:162 : #ack Received response from target: 0x79
00:37:20:163 : Received 4 data bytes from target : 0x01045079
00:37:20:205 : #byte 0x11 sent successfully to target
00:37:20:205 : #byte 0xEE sent successfully to target
00:37:20:308 : #data sent successfully to target: 0x0800000008
00:37:21:310 : Sending Read command and its XOR:
00:37:21:310 : #byte 0x11 sent successfully to target
00:37:21:311 : #byte 0xEE sent successfully to target
00:37:21:321 : Wait ends after 1 loop, dataready = 1, delay = 11
00:37:21:322 : #ack Received response from target: 0x1f
00:37:21:322 : Response received from device: NACK
00:37:21:322 : Error: READ command not acknowledged at address: 0x8000000
00:37:21:322 : Database: Config 0 is active.
00:37:21:323 : Sending GetID command and its XOR:
00:37:21:324 : #byte 0x02 sent successfully to target
00:37:21:324 : #byte 0xFD sent successfully to target
00:37:21:337 : Wait ends after 1 loop, dataready = 1, delay = 14
00:37:21:337 : #ack Received response from target: 0x79
00:37:21:337 : Received 4 data bytes from target : 0x01045079
00:37:22:582 : Sending GetID command and its XOR:
00:37:22:582 : #byte 0x02 sent successfully to target
00:37:22:582 : #byte 0xFD sent successfully to target
00:37:22:582 : Wait ends after 1 loop, dataready = 1, delay = 14
00:37:22:582 : #ack Received response from target: 0x79
00:37:22:582 : Received 4 data bytes from target : 0x01045079
00:37:22:582 : #byte 0x11 sent successfully to target
00:37:22:582 : #byte 0xEE sent successfully to target
00:37:22:582 : #data sent successfully to target: 0x0800000008
00:37:22:582 : UPLOADING OPTION BYTES DATA ...
00:37:22:583 : Bank : 0x00
00:37:22:583 : Address : 0x5200201c
00:37:22:583 : Size : 308 Bytes
00:37:22:583 : Sending Read command and its XOR:
00:37:22:583 : #byte 0x11 sent successfully to target
00:37:22:583 : #byte 0xEE sent successfully to target
00:37:22:583 : Wait ends after 1 loop, dataready = 1, delay = 10
00:37:22:583 : #ack Received response from target: 0x1f
00:37:22:583 : Response received from device: NACK
00:37:22:583 : Error: READ command not acknowledged at address: 0x5200201C
00:37:22:583 : Error: Uploading Option Bytes bank: 0 failed
00:37:22:610 : Error: Initializing the Option Bytes failed
00:37:22:639 : UART PORT CLOSE
00:37:22:639 : Disconnected from device.
00:37:31:421 : Error: Connection to target must be established before performing the erase command.
00:37:31:532 : Disconnected from device.

I don't know what happened, perhaps it is under read protect mode, but I don't know its level and don;t know how to unlock it, help me please